Hair-Growth-Promoting Effects of Fermented Red Ginseng Marc and Traditional Polyherb Formula in C57BL/6 Mice

An abnormal hair-growth cycle induces hair loss, which affects psychological distress and impairs life quality. Red ginseng marc (RGM) is usually discarded as a byproduct after extracting red ginseng, but several studies have shown that the RGM still has bioactive components including ginsenosides. Therefore, effects of fermented (fRGM) traditional polyherb formula (PH) were examined in C57BL/6 mice. The dorsal hairs mice depilated, they topically treated with fRGM or PH at 400, 200 100 mg/kg combination both middle doses (combi) once day for two weeks. hair-covering regions significantly increased higher combi groups, compared control distilled water. Hair length, thickness weight also treatment groups. In particular, anagen-phased follicles, follicular diameters dermal thickness. Immunostains Ki-67 showed cell division beneficial greater high These suggest hair-growth-promoting fRGM, by enhancing cycle.